CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKα2 and enhancing nuclear translocation of Akt1

Cytochrome P450 epoyxgenase 2J2 and epoxyeicosatrienoic acids (EETs) are known to protect against cardiac hypertrophy and heart failure, which involve the activation of 5′‐AMP‐activated protein kinase (AMPK) and Akt. Although the functional roles of AMPK and Akt are well established, the significanc...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Aging Cell
Asıl Yazarlar: Wang, Bei, Zeng, Hesong, Wen, Zheng, Chen, Chen, Wang, Dao Wen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013012/
https://ncbi.nlm.nih.gov/pubmed/27416746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12507
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