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Catalytic Asymmetric Synthesis of Ketene Heterodimer β-Lactones: Scope and Limitations

In this article we describe extensive studies of the catalytic asymmetric heterodimerization of ketenes to give ketene heterodimer β-lactones. The optimal catalytic system was determined to be a cinchona alkaloid derivative (TMS-quinine or Me-quinidine). The desired ketene heterodimer β-lactones wer...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Chen, Shi, Ibrahim, Ahmad A., Peraino, Nicholas J., Nalla, Divya, Mondal, Mukulesh, Van Raaphorst, Maxwell, Kerrigan, Nessan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012991/
https://ncbi.nlm.nih.gov/pubmed/27490092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b01481
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