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Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists
The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, meaning that the human P2X7R (hP2X7R) is an attractive therapeutic target. The crystal structures of the zebrafish P2X4R in the closed and ATP-bound open states provide an unpreced...
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| Publicat a: | Biochem Pharmacol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Science
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5012888/ https://ncbi.nlm.nih.gov/pubmed/27481062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.07.020 |
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