Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF

Selective delivery of drugs to tumor cells can increase potency and reduce toxicity. In this study, we describe a novel recombinant chimeric protein, dsRBEC, which can bind polyIC and deliver it selectively into EGFR over-expressing tumor cells. dsRBEC, comprises the dsRNA binding domain (dsRBD) of...

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Bibliographic Details
Published in:PLoS One
Main Authors: Edinger, Nufar, Lebendiker, Mario, Klein, Shoshana, Zigler, Maya, Langut, Yael, Levitzki, Alexander
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012564/
https://ncbi.nlm.nih.gov/pubmed/27598772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162321
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