A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase

The Sleeping Beauty (SB) transposon system has been shown to enable long-term gene expression by integrating new sequences into host cell chromosomes. We found that the recently reported SB100x hyperactive transposase conferred a surprisingly high level of long-term expression after hydrodynamic del...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Podetz-Pedersen, Kelly M, Olson, Erik R, Somia, Nikunj V, Russell, Stephen J, McIvor, R Scott
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012552/
https://ncbi.nlm.nih.gov/pubmed/26784638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.54
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