Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transformation. Therefore, pharmacologic MNK inhibitors m...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: García-Recio, Eva M, Pinto-Díez, Celia, Pérez-Morgado, M Isabel, García-Hernández, Marta, Fernández, Gerónimo, Martín, M Elena, González, Víctor M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012548/
https://ncbi.nlm.nih.gov/pubmed/26730812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.50
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