RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells

Osteopontin (OPN) is a secreted phosphoprotein which mediates tumorigenesis, local growth, and metastasis in a variety of cancers. It is a potential therapeutic target for the regulation of cancer metastasis. RNA aptamer technology targeting OPN may represent a clinically viable therapy. In this stu...

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Autors principals: Mi, Zhiyong, Guo, Hongtao, Russell, M Benjamin, Liu, Yingmiao, Sullenger, Bruce A, Kuo, Paul C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834992/
https://ncbi.nlm.nih.gov/pubmed/18985031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.235
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