NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage

Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor–post-synaptic density protein-95–neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially...

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Foilsithe in:J Cereb Blood Flow Metab
Main Authors: Kleinschnitz, Christoph, Mencl, Stine, Kleikers, Pamela WM, Schuhmann, Michael K, G López, Manuela, Casas, Ana I, Sürün, Bilge, Reif, Andreas, Schmidt, Harald HHW
Formáid: Artigo
Teanga:Inglês
Foilsithe: SAGE Publications 2016
Ábhair:
Brief Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012526/
https://ncbi.nlm.nih.gov/pubmed/27354091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16657094
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