Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Por Altenhöfer, Sebastian, Radermacher, Kim A., Kleikers, Pamela W.M., Wingler, Kirstin, Schmidt, Harald H.H.W.
Publicado no Antioxid Redox Signal (2015)

NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage

Por Kleinschnitz, Christoph, Mencl, Stine, Kleikers, Pamela WM, Schuhmann, Michael K, G López, Manuela, Casas, Ana I, Sürün, Bilge, Reif, Andreas, Schmidt, Harald HHW
Publicado no J Cereb Blood Flow Metab (2016)

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

Por Kleikers, Pamela WM., Hooijmans, Carlijn, Göb, Eva, Langhauser, Friederike, Rewell, Sarah SJ., Radermacher, Kim, Ritskes-Hoitinga, Merel, Howells, David W., Kleinschnitz, Christoph, HHW Schmidt, Harald
Publicado no Sci Rep (2015)

A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and i...

Por Casas, Ana I, Langhauser, Friederike, Dao, Vu Thao-Vi, Guney, Emre, Kleikers, Pamela WM, López, Manuela García, Menche, Jörg, Barabási, Albert-László, Kleinschnitz, Christoph, Schmidt, Harald HHW
Publicado no BMC Pharmacol Toxicol (2015)