Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory

Rats subjected to bilateral common carotid arteries (CCAs) occlusion or 2-vessel occlusion (2VO) have been used as animal models of subcortical ischemic vascular dementia (SIVD). However, these models possess an inherent limitation in that cerebral blood flow (CBF) drops sharply and substantially af...

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Publicado en:J Cereb Blood Flow Metab
Autores principales: Kitamura, Akihiro, Saito, Satoshi, Maki, Takakuni, Oishi, Naoya, Ayaki, Takashi, Hattori, Yorito, Yamamoto, Yumi, Urushitani, Makoto, Kalaria, Raj N, Fukuyama, Hidenao, Horsburgh, Karen, Takahashi, Ryosuke, Ihara, Masafumi
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2015
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012514/
https://ncbi.nlm.nih.gov/pubmed/26661170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15606717
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