Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory

Rats subjected to bilateral common carotid arteries (CCAs) occlusion or 2-vessel occlusion (2VO) have been used as animal models of subcortical ischemic vascular dementia (SIVD). However, these models possess an inherent limitation in that cerebral blood flow (CBF) drops sharply and substantially af...

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Bibliografske podrobnosti
izdano v:J Cereb Blood Flow Metab
Main Authors: Kitamura, Akihiro, Saito, Satoshi, Maki, Takakuni, Oishi, Naoya, Ayaki, Takashi, Hattori, Yorito, Yamamoto, Yumi, Urushitani, Makoto, Kalaria, Raj N, Fukuyama, Hidenao, Horsburgh, Karen, Takahashi, Ryosuke, Ihara, Masafumi
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2015
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012514/
https://ncbi.nlm.nih.gov/pubmed/26661170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15606717
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