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Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin/NFAT signaling axis

Mechanical forces trigger biological responses in bone cells that ultimately control osteoblastogenesis and bone program. Although several mechanosensors have been postulated, the precise mechanotransduction pathway remains obscure as the initial mechanosensing event has not yet been identified. Stu...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Dalagiorgou, Georgia, Piperi, Christina, Georgopoulou, Urania, Adamopoulos, Christos, Basdra, Efthimia K., Papavassiliou, Athanasios G.
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012114/
https://ncbi.nlm.nih.gov/pubmed/23014991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1164-5
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