Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies have implicated a role for peroxisome proliferator-activated receptor γ coactivator protein-1α (PGC-1α) in PD and in animal or cellular models of PD. The role of PGC-1α in the function and survival of substa...

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Enregistré dans:
Détails bibliographiques
Publié dans:eNeuro
Auteurs principaux: Jiang, Haisong, Kang, Sung-Ung, Zhang, Shuran, Karuppagounder, Senthilkumar, Xu, Jinchong, Lee, Yong-Kyu, Kang, Bong-Gu, Lee, Yunjong, Zhang, Jianmin, Pletnikova, Olga, Troncoso, Juan C., Pirooznia, Shelia, Andrabi, Shaida A., Dawson, Valina L., Dawson, Ted M.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2016
Sujets:
New Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011687/
https://ncbi.nlm.nih.gov/pubmed/27622213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0183-16.2016
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