Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser‐dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was also elevated, correlating with chitotriosidase and CCL1...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Kramer, Gertjan, Wegdam, Wouter, Donker‐Koopman, Wilma, Ottenhoff, Roelof, Gaspar, Paulo, Verhoek, Marri, Nelson, Jessica, Gabriel, Tanit, Kallemeijn, Wouter, Boot, Rolf G., Laman, Jon D., Vissers, Johannes P.C., Cox, Timothy, Pavlova, Elena, Moran, Mary Teresa, Aerts, Johannes M., van Eijk, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011488/
https://ncbi.nlm.nih.gov/pubmed/27642553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12078
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