Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation

PURPOSE: Peroxynitrite plays a critical role in vascular pathophysiology by increasing arginase activity and decreasing endothelial nitric oxide synthase (eNOS) activity. Therefore, the aims of this study were to investigate whether arginase inhibition and L-arginine supplement could restore peroxyn...

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Detalhes bibliográficos
Publicado no:Yonsei Med J
Main Authors: Nguyen, Minh Cong, Park, Jong Taek, Jeon, Yeong Gwan, Jeon, Byeong Hwa, Hoe, Kwang Lae, Kim, Young Myeong, Lim, Hyun Kyo, Ryoo, Sungwoo
Formato: Artigo
Idioma:Inglês
Publicado em: Yonsei University College of Medicine 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011263/
https://ncbi.nlm.nih.gov/pubmed/27593859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2016.57.6.1329
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