Difference in CXCR4 expression between sporadic and VHL-related hemangioblastoma

Central nervous system hemangioblastomas occur sporadically and in patients with von Hippel–Lindau (VHL) disease due to a VHL germline mutation. This mutation leads to enhanced transcription of chemokine receptor 4 (CXCR4), its ligand (CXCL12) and vascular endothelial growth factor A (VEGFA). We aim...

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Udgivet i:Fam Cancer
Main Authors: Kruizinga, Roeliene C., van Marion, Denise M. S., den Dunnen, Wilfred F. A., de Groot, Jan C., Hoving, Eelco W., Oosting, Sjoukje F., Timmer-Bosscha, Hetty, Derks, Rosalie P. H., Cornelissen, Chantal, van der Luijt, Rob B., Links, Thera P., de Vries, Elisabeth G. E., Walenkamp, Annemiek M. E.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010837/
https://ncbi.nlm.nih.gov/pubmed/26920352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-016-9879-3
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