Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax

BACKGROUND: The subterranean blind mole rat, Spalax (genus Nannospalax) endures extreme hypoxic conditions and fluctuations in oxygen levels that threaten DNA integrity. Nevertheless, Spalax is long-lived, does not develop spontaneous cancer, and exhibits an outstanding resistance to carcinogenesis...

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Detalhes bibliográficos
Publicado no:BMC Evol Biol
Main Authors: Domankevich, Vered, Opatowsky, Yarden, Malik, Assaf, Korol, Abraham B., Frenkel, Zeev, Manov, Irena, Avivi, Aaron, Shams, Imad
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010716/
https://ncbi.nlm.nih.gov/pubmed/27590526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-016-0743-8
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