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The role of integrins in TGFβ activation in the tumour stroma
TGFβ1 is the most pleiotropic of all known cytokines and thus, to avoid uncontrolled TGFβ-activated processes, its activity is tightly regulated. Studies in fibrosis have led to the discovery that αv integrins are the major regulators of the local activation of latent TGFβ in our tissues. Since all...
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| Veröffentlicht in: | Cell Tissue Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Berlin Heidelberg
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5010607/ https://ncbi.nlm.nih.gov/pubmed/27515461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-016-2474-y |
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