A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Multiple Myeloma Patients

PURPOSE: Painful peripheral neuropathy is a frequent toxicity associated with bortezomib therapy. This study aimed to identify loci that affect susceptibility to this toxicity. EXPERIMENTAL DESIGN: A genome-wide association study (GWAS) of 370,605 SNPs was performed to identify risk variants for dev...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Magrangeas, Florence, Kuiper, Rowan, Avet-Loiseau, Hervé, Gouraud, Wilfried, Guérin-Charbonnel, Catherine, Ferrer, Ludovic, Aussem, Alexandre, Elghazel, Haytham, Suhard, Jérôme, Sakissian, Henri Der, Attal, Michel, C.Munshi, Nikhil, Sonneveld, Pieter, Dumontet, Charles, Moreau, Philippe, van Duin, Mark, Campion, Loïc, Minvielle, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010494/
https://ncbi.nlm.nih.gov/pubmed/27060151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-3163
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