Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 c...

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Publicat a:Cancer Res
Autors principals: Fehringer, Gordon, Kraft, Peter, Pharoah, Paul D., Eeles, Rosalind A., Chatterjee, Nilanjan, Schumacher, Fred, Schildkraut, Joellen, Lindström, Sara, Brennan, Paul, Bickeböller, Heike, Houlston, Richard S., Landi, Maria Teresa, Caporaso, Neil, Risch, Angela, Olama, Ali Amin Al, Berndt, Sonja I, Giovannucci, Edward, Grönberg, Henrik, Kote-Jarai, Zsofia, Ma, Jing, Muir, Kenneth, Stampfer, Meir, Stevens, Victoria L., Wiklund, Fredrik, Willett, Walter, Goode, Ellen L., Permuth, Jennifer, Risch, Harvey A., Reid, Brett M., Bezieau, Stephane, Brenner, Hermann, Chan, Andrew T., Chang-Claude, Jenny, Hudson, Thomas J., Kocarnik, Jonathan K., Newcomb, Polly A., Schoen, Robert E., Slattery, Martha L., White, Emily, Adank, Muriel A., Ahsan, Habibul, Aittomäki, Kristiina, Baglietto, Laura, Blomquist, Carl, Canzian, Federico, Czene, Kamila, dos-Santos-Silva, Isabel, Eliassen, A. Heather, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Garcia-Closas, Montserrat, Gaudet, Mia M., Johnson, Nichola, Hall, Per, Hazra, Aditi, Hein, Rebecca, Hofman, Albert, Hopper, John L., Irwanto, Astrid, Johansson, Mattias, Kaaks, Rudolf, Kibriya, Muhammad G., Lichtner, Peter, Liu, Jianjun, Lund, Eiliv, Makalic, Enes, Meindl, Alfons, Müller-Myhsok, Bertram, Muranen, Taru A., Nevanlinna, Heli, Peeters, Petra H., Peto, Julian, Prentice, Ross L., Rahman, Nazneen, Sanchez, Maria Jose, Schmidt, Daniel F., Schmutzler, Rita K., Southey, Melissa C., Tamimi, Rulla, Travis, Ruth C., Turnbull, Clare, Uitterlinden, Andre G., Wang, Zhaoming, Whittemore, Alice S., Yang, Xiaohong R., Zheng, Wei, Rafnar, Thorunn, Gudmundsson, Julius, Stacey, Simon N., Stefansson, Kari, Sulem, Patrick, Chen, Y. Ann, Tyrer, Jonathan P., Christiani, David C., Wei, Yongyue, Shen, Hongbing, Hu, Zhibin, Shu, Xiao-Ou, Shiraishi, Kouya, Takahashi, Atsushi, Bossé, Yohan, Obeidat, Ma’en, Nickle, David, Timens, Wim, Freedman, Matthew L., Li, Qiyuan, Seminara, Daniela, Chanock, Stephen J., Gong, Jian, Peters, Ulrike, Gruber, Stephen B., Amos, Christopher I., Sellers, Thomas A., Easton, Douglas F., Hunter, David J., Haiman, Christopher A., Henderson, Brian E., Hung, Rayjean J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010493/
https://ncbi.nlm.nih.gov/pubmed/27197191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2980
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