Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression

In contrast to its inhibitory effects on many cells, IL-10 activates CD8(+) tumor infiltrating lymphocytes (TILs) and enhances their antitumor activity. However, CD8(+) TILs do not routinely express IL-10 as autocrine complement C3 inhibits IL-10 production through complement receptors C3aR and C5aR...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Wang, Yu, Sun, Sheng-Nan, Liu, Qing, Yu, Yang-Yang, Guo, Jian, Wang, Kun, Xing, Bao-Cai, Zheng, Qing-Feng, Campa, Michael J., Patz, Edward F., Li, Shi-You, He, You-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010476/
https://ncbi.nlm.nih.gov/pubmed/27297552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1412
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