Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T cells (Tregs) are reduced in number and function. The aim of this study was to further characterize Treg subpopulations i...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Kordasti, Shahram, Costantini, Benedetta, Seidl, Thomas, Perez Abellan, Pilar, Martinez Llordella, Marc, McLornan, Donal, Diggins, Kirsten E., Kulasekararaj, Austin, Benfatto, Cinzia, Feng, Xingmin, Smith, Alexander, Mian, Syed A., Melchiotti, Rossella, de Rinaldis, Emanuele, Ellis, Richard, Petrov, Nedyalko, Povoleri, Giovanni A. M., Chung, Sun Sook, Thomas, N. Shaun B., Farzaneh, Farzin, Irish, Jonathan M., Heck, Susanne, Young, Neal S., Marsh, Judith C. W., Mufti, Ghulam J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009512/
https://ncbi.nlm.nih.gov/pubmed/27281795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-703702
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