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Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status

The most frequent genetic alteration identified in pediatric pilocytic astrocytomas and pilomyxoid variant is the KIAA1549-BRAF fusion, which typically results from a 2.0 Mb tandem duplication in chromosome band 7q34. Less frequent abnormalities include fusion genes, BRAF, FGFR, KRAS, and NF1 point...

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Bibliografske podrobnosti
izdano v:J Neuropathol Exp Neurol
Main Authors: Roth, Jacquelyn J., Fierst, Tamara M., Waanders, Angela J., Yimei, Li, Biegel, Jaclyn A., Santi, Mariarita
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009478/
https://ncbi.nlm.nih.gov/pubmed/26945035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlw001
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