An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin

Considerable mechanistic insight has been gained into amyloid aggregation; however, a large number of non-amyloid protein aggregates are considered “amorphous,” and in most cases, little is known about their mechanisms. Amorphous aggregation of γ-crystallins in the eye lens causes cataract, a widesp...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Serebryany, Eugene, Woodard, Jaie C., Adkar, Bharat V., Shabab, Mohammed, King, Jonathan A., Shakhnovich, Eugene I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009285/
https://ncbi.nlm.nih.gov/pubmed/27417136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735977
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