Φορτώνει......
Dynamic disulfide exchange in a crystallin protein in the human eye lens promotes cataract-associated aggregation
Increased light scattering in the eye lens due to aggregation of the long-lived lens proteins, crystallins, is the cause of cataract disease. Several mutations in the gene encoding human γD-crystallin (HγD) cause misfolding and aggregation. Cataract-associated substitutions at Trp(42) cause the prot...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Biol Chem |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Biochemistry and Molecular Biology
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6240864/ https://ncbi.nlm.nih.gov/pubmed/30242128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004551 |
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