NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells. Altered transcript expression of genes encoding other biosynthetic enzymes or proteoglycan...

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Udgivet i:J Biol Chem
Main Authors: Deligny, Audrey, Dierker, Tabea, Dagälv, Anders, Lundequist, Anders, Eriksson, Inger, Nairn, Alison V., Moremen, Kelley W., Merry, Catherine L. R., Kjellén, Lena
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009238/
https://ncbi.nlm.nih.gov/pubmed/27387504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.744433
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