MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2. The interactions between VEGFA and proteoglycan co-receptors require sulfated domains in the HS chains. To date, it i...

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Detalhes bibliográficos
Main Authors: Kasza, Zsolt, Fredlund Fuchs, Peder, Tamm, Christoffer, Eriksson, Anna S., O'Callaghan, Paul, Heindryckx, Femke, Spillmann, Dorothe, Larsson, Erik, Le Jan, Sébastien, Eriksson, Inger, Gerwins, Pär, Kjellén, Lena, Kreuger, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764800/
https://ncbi.nlm.nih.gov/pubmed/23884416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484360
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