MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2. The interactions between VEGFA and proteoglycan co-receptors require sulfated domains in the HS chains. To date, it i...

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Bibliografske podrobnosti
Main Authors: Kasza, Zsolt, Fredlund Fuchs, Peder, Tamm, Christoffer, Eriksson, Anna S., O'Callaghan, Paul, Heindryckx, Femke, Spillmann, Dorothe, Larsson, Erik, Le Jan, Sébastien, Eriksson, Inger, Gerwins, Pär, Kjellén, Lena, Kreuger, Johan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Glycobiology and Extracellular Matrices
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764800/
https://ncbi.nlm.nih.gov/pubmed/23884416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484360
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