Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26

Human dual-specificity phosphatase 26 (DUSP26) is a novel target for anticancer therapy because its dephosphorylation of the p53 tumor suppressor regulates the apoptosis of cancer cells. DUSP26 inhibition results in neuroblastoma cell cytotoxicity through p53-mediated apoptosis. Despite the previous...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Won, Eun-Young, Lee, Sang-Ok, Lee, Dong-Hwa, Lee, Daeyoup, Bae, Kwang-Hee, Lee, Sang Chul, Kim, Seung Jun, Chi, Seung-Wook
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008780/
https://ncbi.nlm.nih.gov/pubmed/27583453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162115
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