Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase

T-cell-originated protein kinase (TOPK) is highly expressed in several cancer cells and promotes tumorigenesis and progression, and therefore, it is an important target for drug treatment of tumor. Pantoprazole (PPZ) was identified to be a TOPK inhibitor from FDA-approved drug database by structure...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zeng, Xiaoyu, Liu, Lin, Zheng, Mengzhu, Sun, Huimin, Xiao, Juanjuan, Lu, Tao, Huang, Guangqian, Chen, Pianpian, Zhang, Jianmin, Zhu, Feng, Li, Hua, Duan, Qiuhong
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008373/
https://ncbi.nlm.nih.gov/pubmed/26967058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7984
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