High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid

Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL). As a key transcription factor of the Wnt/β-catenin pathway, LEF1 helps to regulate important genes involved in tumor cell death mechanisms. In this s...

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Vydáno v:Oncotarget
Hlavní autoři: Wu, Wei, Zhu, Huayuan, Fu, Yuan, Shen, Wenyi, Miao, Kourong, Hong, Min, Xu, Wei, Fan, Lei, Young, Ken H., Liu, Peng, Li, Jianyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008311/
https://ncbi.nlm.nih.gov/pubmed/26950276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7795
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