Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy

BACKGROUND: In patients receiving preoperative chemotherapy, colorectal liver metastases (CLM) are expected to demonstrate a similar behaviour because of similar organ microenvironment and tumour cell chemosensitivity. We focused on the occurrence of pathological and genetic heterogeneity within CLM...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Sebagh, Mylène, Allard, Marc-Antoine, Bosselut, Nelly, Dao, Myriam, Vibert, Eric, Lewin, Maïté, Lemoine, Antoinette, Cherqui, Daniel, Adam, René, Cunha, Antonio Sa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008308/
https://ncbi.nlm.nih.gov/pubmed/26943031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7809
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