The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence

AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Burla, Romina, Carcuro, Mariateresa, Torre, Mattia La, Fratini, Federica, Crescenzi, Marco, D'Apice, Maria Rosaria, Spitalieri, Paola, Raffa, Grazia Daniela, Astrologo, Letizia, Lattanzi, Giovanna, Cundari, Enrico, Raimondo, Domenico, Biroccio, Annamaria, Gatti, Maurizio, Saggio, Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008010/
https://ncbi.nlm.nih.gov/pubmed/27512140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160103
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