Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

Transforming growth factor beta (TGFbeta) plays an essential role in bone homeostasis and deregulation of TGFbeta occurs in bone pathologies. Patients affected by Mandibuloacral Dysplasia (MADA), a progeroid disease linked to LMNA mutations, suffer from an osteolytic process. Our previous work showe...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Evangelisti, Camilla, Bernasconi, Pia, Cavalcante, Paola, Cappelletti, Cristina, D'Apice, Maria Rosaria, Sbraccia, Paolo, Novelli, Giuseppe, Prencipe, Sabino, Lemma, Silvia, Baldini, Nicola, Avnet, Sofia, Squarzoni, Stefano, Martelli, Alberto M., Lattanzi, Giovanna
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2015
Onderwerpen:
Gerotarget (Focus on Aging): Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480690/
https://ncbi.nlm.nih.gov/pubmed/25823658
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