Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

Transforming growth factor beta (TGFbeta) plays an essential role in bone homeostasis and deregulation of TGFbeta occurs in bone pathologies. Patients affected by Mandibuloacral Dysplasia (MADA), a progeroid disease linked to LMNA mutations, suffer from an osteolytic process. Our previous work showe...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Evangelisti, Camilla, Bernasconi, Pia, Cavalcante, Paola, Cappelletti, Cristina, D'Apice, Maria Rosaria, Sbraccia, Paolo, Novelli, Giuseppe, Prencipe, Sabino, Lemma, Silvia, Baldini, Nicola, Avnet, Sofia, Squarzoni, Stefano, Martelli, Alberto M., Lattanzi, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Gerotarget (Focus on Aging): Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480690/
https://ncbi.nlm.nih.gov/pubmed/25823658
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