Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts

Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: McCallum, Melissa L., Pru, Cindy A., Niikura, Yuichi, Yee, Siu-Pok, Lydon, John P., Peluso, John J., Pru, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007897/
https://ncbi.nlm.nih.gov/pubmed/27309940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1081
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