TNIK inhibition abrogates colorectal cancer stemness

Canonical Wnt/β-catenin signalling is essential for maintaining intestinal stem cells, and its constitutive activation has been implicated in colorectal carcinogenesis. We and others have previously identified Traf2- and Nck-interacting kinase (TNIK) as an essential regulatory component of the T-cel...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Masuda, Mari, Uno, Yuko, Ohbayashi, Naomi, Ohata, Hirokazu, Mimata, Ayako, Kukimoto-Niino, Mutsuko, Moriyama, Hideki, Kashimoto, Shigeki, Inoue, Tomoko, Goto, Naoko, Okamoto, Koji, Shirouzu, Mikako, Sawa, Masaaki, Yamada, Tesshi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007443/
https://ncbi.nlm.nih.gov/pubmed/27562646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12586
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items