Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer()

Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) inhibitors decreasing serum cholesterol and have shown promise in cancer prevention. In this study, we demonstrated the oncogenic role of HMGR in colorectal cancer (CRC) by disclosing increased HMGR activity in CRC patients...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Wei, Tzu-Tang, Lin, Yi-Ting, Chen, Wen-Shu, Luo, Ping, Lin, Yu-Chin, Shun, Chia-Tung, Lin, Yi-Hsin, Chen, Jhih-Bin, Chen, Nai-Wei, Fang, Jim-Min, Wu, Ming-Shiang, Yang, Kai-Chien, Chang, Li-Chun, Tai, Kang-Yu, Liang, Jin-Tung, Chen, Ching-Chow
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006731/
https://ncbi.nlm.nih.gov/pubmed/27448759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.07.019
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