Combined MYC activation and Pten loss are sufficient to create genomic instability and lethal metastatic prostate cancer

Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations are found in most aggressive primary human prostate cancers, and the overall number of such changes is increased in metastases. Chromoso...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Hubbard, Gretchen K., Mutton, Laura N., Khalili, May, McMullin, Ryan P., Hicks, Jessica L., Bianchi-Frias, Daniella, Horn, Lucas A., Kulac, Ibrahim, Moubarek, Michael S., Nelson, Peter S., Yegnasubramanian, Srinivasan, De Marzo, Angelo M., Bieberich, Charles J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006678/
https://ncbi.nlm.nih.gov/pubmed/26554830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3280
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