Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption

BACKGROUND: CD8 T cell-mediated blood-brain barrier (BBB) disruption is dependent on the effector molecule perforin. Human perforin has extensive single nucleotide variants (SNVs), the significance of which is not fully understood. These SNVs can result in reduced, but not ablated, perforin activity...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Willenbring, Robin C., Jin, Fang, Hinton, David J., Hansen, Mike, Choi, Doo-Sup, Pavelko, Kevin D., Johnson, Aaron J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006384/
https://ncbi.nlm.nih.gov/pubmed/27576583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0673-9
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