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Disease-Associated Mutations in the HSPD1 Gene Encoding the Large Subunit of the Mitochondrial HSP60/HSP10 Chaperonin Complex

Heat shock protein 60 (HSP60) forms together with heat shock protein 10 (HSP10) double-barrel chaperonin complexes that are essential for folding to the native state of proteins in the mitochondrial matrix space. Two extremely rare monogenic disorders have been described that are caused by missense...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Bross, Peter, Fernandez-Guerra, Paula
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006179/
https://ncbi.nlm.nih.gov/pubmed/27630992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00049
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