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Protein backbone ensemble generation explores the local structural space of unseen natural homologs

Motivation: Mutations in homologous proteins affect changes in the backbone conformation that involve a complex interplay of forces which are difficult to predict. Protein design algorithms need to anticipate these backbone changes in order to accurately calculate the energy of the structure given a...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Schenkelberg, Christian D., Bystroff, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006151/
https://ncbi.nlm.nih.gov/pubmed/26787668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw001
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