Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

Disorders of glucose homeostasis are common in chronic kidney disease (CKD) and are associated with increased mortality, but the mechanisms of impaired insulin secretion in this disease remain unclear. Here, we tested the hypothesis that defective insulin secretion in CKD is caused by a direct effec...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Koppe, Laetitia, Nyam, Elsa, Vivot, Kevin, Manning Fox, Jocelyn E., Dai, Xiao-Qing, Nguyen, Bich N., Trudel, Dominique, Attané, Camille, Moullé, Valentine S., MacDonald, Patrick E., Ghislain, Julien, Poitout, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004963/
https://ncbi.nlm.nih.gov/pubmed/27525435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86181
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