Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing

Macrophages contribute to the development of atherosclerosis through pinocytotic deposition of native LDL–derived cholesterol in macrophages in the vascular wall. Inhibiting macrophage-mediated lipid deposition may have protective effects in atheroprone vasculature, and identifying mechanisms that p...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Miyazaki, Takuro, Tonami, Kazuo, Hata, Shoji, Aiuchi, Toshihiro, Ohnishi, Koji, Lei, Xiao-Feng, Kim-Kaneyama, Joo-ri, Takeya, Motohiro, Itabe, Hiroyuki, Sorimachi, Hiroyuki, Kurihara, Hiroki, Miyazaki, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004959/
https://ncbi.nlm.nih.gov/pubmed/27525442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85880
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