Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas

Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein α subunit (GNAS) are found in approximately 70% of ATAs. The involvement of other genes and the pathogenesis of the remaining cases are presently unkn...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Calebiro, Davide, Grassi, Elisa S., Eszlinger, Markus, Ronchi, Cristina L., Godbole, Amod, Bathon, Kerstin, Guizzardi, Fabiana, de Filippis, Tiziana, Krohn, Knut, Jaeschke, Holger, Schwarzmayr, Thomas, Bircan, Rifat, Gozu, Hulya Iliksu, Sancak, Seda, Niedziela, Marek, Strom, Tim M., Fassnacht, Martin, Persani, Luca, Paschke, Ralf
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2016
Teme:
Brief Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004945/
https://ncbi.nlm.nih.gov/pubmed/27500488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84894
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