Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas

Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein α subunit (GNAS) are found in approximately 70% of ATAs. The involvement of other genes and the pathogenesis of the remaining cases are presently unkn...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Calebiro, Davide, Grassi, Elisa S., Eszlinger, Markus, Ronchi, Cristina L., Godbole, Amod, Bathon, Kerstin, Guizzardi, Fabiana, de Filippis, Tiziana, Krohn, Knut, Jaeschke, Holger, Schwarzmayr, Thomas, Bircan, Rifat, Gozu, Hulya Iliksu, Sancak, Seda, Niedziela, Marek, Strom, Tim M., Fassnacht, Martin, Persani, Luca, Paschke, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004945/
https://ncbi.nlm.nih.gov/pubmed/27500488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84894
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