Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

BACKGROUND. T cells expressing antigen-specific chimeric antigen receptors (CARs) improve outcomes for CD19-expressing B cell malignancies. We evaluated a human application of T cells that were genetically modified using the Sleeping Beauty (SB) transposon/transposase system to express a CD19-specif...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Kebriaei, Partow, Singh, Harjeet, Huls, M. Helen, Figliola, Matthew J., Bassett, Roland, Olivares, Simon, Jena, Bipulendu, Dawson, Margaret J., Kumaresan, Pappanaicken R., Su, Shihuang, Maiti, Sourindra, Dai, Jianliang, Moriarity, Branden, Forget, Marie-Andrée, Senyukov, Vladimir, Orozco, Aaron, Liu, Tingting, McCarty, Jessica, Jackson, Rineka N., Moyes, Judy S., Rondon, Gabriela, Qazilbash, Muzaffar, Ciurea, Stefan, Alousi, Amin, Nieto, Yago, Rezvani, Katy, Marin, David, Popat, Uday, Hosing, Chitra, Shpall, Elizabeth J., Kantarjian, Hagop, Keating, Michael, Wierda, William, Do, Kim Anh, Largaespada, David A., Lee, Dean A., Hackett, Perry B., Champlin, Richard E., Cooper, Laurence J.N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2016
Pynciau:
Clinical Medicine
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004935/
https://ncbi.nlm.nih.gov/pubmed/27482888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86721
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