Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

Some compounds of a series of novel pyrrolo-1,5-benzoxa(thia)zepine, a well-known group of tubulin targeting agents, display anti-tumor effects mainly inducing cell cycle arrest and apoptosis in several human cancer models. A member of this family, pyrrolo-1,5-benzoxazepine-15 (PBOX-15), has previou...

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Vydáno v:Cancer Biol Ther
Hlavní autoři: Fiore, Donatella, Proto, Maria Chiara, Pisanti, Simona, Picardi, Paola, Pagano Zottola, Antonio Christian, Butini, Stefania, Gemma, Sandra, Casagni, Alice, Laezza, Chiara, Vitale, Mario, Ligresti, Alessia, Di Marzo, Vincenzo, Zisterer, Daniela M., Nathwani, Seema, Williams, D. Clive, Campiani, Giuseppe, Gazzerro, Patrizia, Bifulco, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004676/
https://ncbi.nlm.nih.gov/pubmed/26392056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1078028
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