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The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells

Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel strategies that counteract apoptotic resistance. The death ligand TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) and its selecti...

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Detalhes bibliográficos
Publicado no:Int J Oncol
Main Authors: NATHWANI, SEEMA-MARIA, GREENE, LISA M., BUTINI, STEFANIA, CAMPIANI, GIUSEPPE, WILLIAMS, D. CLIVE, SAMALI, AFSHIN, SZEGEZDI, EVA, ZISTERER, DANIELA M.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902072/
https://ncbi.nlm.nih.gov/pubmed/27176505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2016.3518
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