Far Upstream Element-Binding Protein 1 Binds the 3′ Untranslated Region of PKD2 and Suppresses Its Translation

Autosomal dominant polycystic kidney disease pathogenesis can be recapitulated in animal models by gene mutations in or dosage alterations of polycystic kidney disease 1 (PKD1) or PKD2, demonstrating that too much and too little PKD1/PKD2 are both pathogenic. Gene dosage manipulation has become an a...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Zheng, Wang, Shen, Fan, Hu, Ruikun, Roy, Birbickram, Yang, JungWoo, Wang, Qian, Zhang, Fan, King, Jennifer C., Sergi, Consolato, Liu, Song-Mei, Cordat, Emmanuelle, Tang, Jingfeng, Cao, Ying, Ali, Declan, Chen, Xing-Zhen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2016
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004656/
https://ncbi.nlm.nih.gov/pubmed/26839368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070836
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