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Probing extracellular Sonic hedgehog in neurons
The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in extracellular space. Multiple lines of evidenc...
Uloženo v:
| Vydáno v: | Biol Open |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Company of Biologists Ltd
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5004615/ https://ncbi.nlm.nih.gov/pubmed/27387534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.019422 |
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