Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene

Hodgkin lymphoma shows strong familial aggregation but no major susceptibility genes have been identified to date. The goal of this study was to identify high-penetrance variants using whole exome sequencing in 17 Hodgkin lymphoma prone families with three or more affected cases or obligate carriers...

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Publié dans:Haematologica
Auteurs principaux: Rotunno, Melissa, McMaster, Mary L., Boland, Joseph, Bass, Sara, Zhang, Xijun, Burdett, Laurie, Hicks, Belynda, Ravichandran, Sarangan, Luke, Brian T., Yeager, Meredith, Fontaine, Laura, Hyland, Paula L., Goldstein, Alisa M., Chanock, Stephen J., Caporaso, Neil E., Tucker, Margaret A., Goldin, Lynn R.
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2016
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004465/
https://ncbi.nlm.nih.gov/pubmed/27365461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.135475
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