Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene

Hodgkin lymphoma shows strong familial aggregation but no major susceptibility genes have been identified to date. The goal of this study was to identify high-penetrance variants using whole exome sequencing in 17 Hodgkin lymphoma prone families with three or more affected cases or obligate carriers...

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Pubblicato in:Haematologica
Autori principali: Rotunno, Melissa, McMaster, Mary L., Boland, Joseph, Bass, Sara, Zhang, Xijun, Burdett, Laurie, Hicks, Belynda, Ravichandran, Sarangan, Luke, Brian T., Yeager, Meredith, Fontaine, Laura, Hyland, Paula L., Goldstein, Alisa M., Chanock, Stephen J., Caporaso, Neil E., Tucker, Margaret A., Goldin, Lynn R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004465/
https://ncbi.nlm.nih.gov/pubmed/27365461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.135475
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